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A note on the contamination of eye-drops following use by hospital out-patients
Journal of Clinical and Hospital Pharmacy
|June 1, 1985
Abstract:
Examination of 273 eye-drops, returned to a hospital pharmacy by out-patients showed that 27% were contaminated. Common contaminants included Bacillus spp, Staphylococcus albus and Sarcina spp. Those eye-drops containing the preservatives chlorbutol or thiomersal showed above average levels of contamination, thus questioning the suitability of these preservatives for ophthalmic preparations.
Insights
A study found 27% of returned eye-drops were contaminated with bacteria like Bacillus spp. Preservatives chlorbutol and thiomersal were associated with higher contamination levels, questioning their effectiveness in ophthalmic preparations.
Area of Science:
- Microbiology
- Ophthalmology
- Pharmaceutical Science
Background:
- Ophthalmic preparations require sterile administration to prevent ocular infections.
- Preservatives are commonly used in multi-dose eye-drop formulations to inhibit microbial growth.
- The efficacy and safety of preservatives in maintaining sterility are critical.
Purpose of the Study:
- To assess the microbial contamination rates of eye-drops returned by outpatients.
- To identify common microbial contaminants in these ophthalmic preparations.
- To evaluate the effectiveness of commonly used preservatives (chlorbutol, thiomersal) in preventing contamination.
Main Methods:
- Analysis of 273 returned eye-drop samples from hospital outpatients.
- Microbiological culturing to identify and quantify microbial contaminants.
- Statistical comparison of contamination levels in eye-drops with and without specific preservatives.
Main Results:
- A significant 27% of the examined eye-drop samples were found to be contaminated.
- Predominant contaminants identified included Bacillus spp., Staphylococcus albus, and Sarcina spp.
- Eye-drops containing chlorbutol or thiomersal exhibited higher-than-average contamination rates.
Conclusions:
- The study highlights a concerning level of microbial contamination in patient-returned eye-drops.
- The preservatives chlorbutol and thiomersal appear to be less effective than anticipated in sterile ophthalmic preparations.
- Further investigation into alternative or improved preservative systems for eye-drops is warranted to ensure patient safety.