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The Complex Puzzle of Hypertrophic Phenotype: A Practical Approach for the Clinician

Alex Dos Santos Felix1,2,3,4, Silvio Henrique Barberato5,6, Marcelo Dantas Tavares de Melo7

  • 1Instituto Nacional de Cardiologia, Rio de Janeiro, RJ - Brasil.

Arquivos Brasileiros De Cardiologia
|April 8, 2025
PubMed

Insights

Differentiating causes of left ventricular hypertrophy (LVH) is crucial for effective treatment. This review offers a practical approach using clinical assessment and cardiovascular imaging to diagnose diverse LVH etiologies accurately.

Area of Science:

  • Cardiology
  • Medical Diagnostics

Background:

  • Left ventricular hypertrophy (LVH) is a common clinical finding with diverse underlying causes.
  • Accurate differentiation of LVH etiologies is essential for appropriate therapeutic strategies and improved patient outcomes.
  • Misdiagnosis or delayed diagnosis can lead to disease progression, reduced functional capacity, and increased morbidity and mortality.

Purpose of the Study:

  • To provide a pragmatic methodology for discriminating among the various conditions causing LVH.
  • To highlight key diagnostic clues for clinicians managing patients with LVH.
  • To emphasize the importance of an integrative approach in evaluating patients with LVH.

Main Methods:

  • Review of clinical assessment and electrocardiographic findings in LVH diagnosis.
  • Emphasis on the role of cardiovascular multimodality imaging as a critical diagnostic tool.
  • Integration of data from various medical specialties for a comprehensive patient evaluation.

Main Results:

  • Cardiovascular multimodality imaging, combined with clinical and ECG data, is vital for solving diagnostic challenges in LVH.
  • An integrative approach involving a multidisciplinary team is recommended for optimized patient follow-up.
  • The clinician plays a central role in coordinating data for an assertive diagnosis of LVH.

Conclusions:

  • A systematic and integrative approach is necessary for accurate diagnosis and management of LVH.
  • Identifying the specific etiology of LVH guides tailored treatment, preventing adverse outcomes.
  • This review provides essential insights for clinicians to navigate the complexities of LVH diagnosis.

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