PERITUMORAL BUDDING AS A PREDICTOR FOR LYMPH NODE METASTASES IN COLORECTAL CARCINOMAS: WHAT IS THE IMPORTANCE?

Area of Science:

• Oncology
• Pathology
• Surgical Oncology

Background:

• Microscopic analysis of tumor budding (TB) is a potential predictive tool for lymph node metastases in colorectal cancer.
• Patients in intermediate stages show significant prognostic variability.

Purpose of the Study:

• To evaluate the predictive power of tumor budding (TB) for lymph node metastases.
• To assess the association of TB with colorectal carcinoma progression characteristics.

Main Methods:

• Retrospective, cross-sectional study with a quantitative approach.
• Review of medical records and histopathological reports from 153 colorectal cancer patients.

Main Results:

• 97 cases (63.39%) exhibited tumor budding (TB), with 51.55% having a high budding score.
• A statistically significant association was found between TB and lymph node metastasis (p<0.05).
• Regional lymph node metastases were observed in 66 patients.

Conclusions:

• Tumor budding (TB) is significant for risk stratification and prognosis in colorectal cancer, complementing TNM staging.
• Assessment of TB in histopathology reports is crucial for therapeutic decisions.