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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Localized Cancer Treatment Using Thiol-Ene Hydrogels for Dual Drug Delivery.

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This study developed an injectable hydrogel for combinatorial cancer therapy, enabling controlled drug delivery. The tumor-responsive system effectively delivered drugs and inhibited cancer cells, offering a promising minimally invasive treatment.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Cancer Therapy

Background:

  • Combinatorial cancer therapy requires localized, controlled drug delivery.
  • Injectable hydrogels offer a promising solution for localized drug delivery.
  • Hyaluronic acid and β-cyclodextrin are suitable components for hydrogel development.

Purpose of the Study:

  • To develop and characterize a novel injectable hydrogel for combinatorial cancer therapy.
  • To evaluate the drug release kinetics and tumor-responsiveness of the hydrogel.
  • To assess the biocompatibility and anti-cancer efficacy of the hydrogel system.

Main Methods:

  • Synthesis of thiol-ene conjugated hydrogels via cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS).
  • Rheological analysis to determine viscoelastic properties of different hydrogel formulations.
  • In vitro drug release studies (doxorubicin and carvacrol) under physiological and tumor-mimicking conditions.
  • Assessment of hydrogel degradation, mesenchymal stem cell proliferation, and triple-negative breast cancer cell inhibition.

Main Results:

  • Four hydrogel formulations were successfully synthesized with varying HASH molecular weights and CDVS modifications.
  • Rheological properties showed increased viscoelasticity with higher molecular weight and modification.
  • The hydrogel demonstrated tumor-responsive degradation and tunable release profiles for doxorubicin and carvacrol.
  • The system promoted stem cell proliferation and exhibited significant inhibition of triple-negative breast cancer cells.

Conclusions:

  • The developed injectable hydrogel system is a promising platform for localized, controlled combinatorial cancer therapy.
  • The tumor-responsive nature and tunable drug release offer potential for personalized cancer treatment.
  • This minimally invasive approach holds potential for effective cancer treatment strategies.