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Updated: May 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: February 6, 2019

A Reminder App to Optimize Bladder Filling During Radiotherapy for Patients With Prostate Cancer (REFILL-PAC):

Dirk Rades^1,2, Jan-Dirk Küter¹, Michael von Staden¹

¹Department of Radiation Oncology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lubeck, Germany.

JMIR Research Protocols

|April 8, 2025

Summary

A mobile app reminds prostate cancer patients to drink water before radiotherapy, aiming to increase bladder volume and reduce urinary toxicity. This study assesses the app's effectiveness in maintaining adequate bladder filling during treatment.

Keywords:

bladder filling external beam radiation therapy mobile app prostate cancer radiation toxicity

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Area of Science:

Oncology
Radiotherapy
Urology

Background:

Radiotherapy for prostate cancer can cause acute cystitis, especially with small bladder volumes (<200 ml).
Maintaining bladder volumes >200 ml during radiotherapy fractions is crucial for minimizing urinary toxicity.
Patient adherence to pre-radiation drinking protocols can be challenging.

Purpose of the Study:

To evaluate the impact of a mobile app reminder system on bladder volume.
To determine if the app increases the number of radiotherapy fractions with bladder volumes >200 ml.
To assess the app's effect on urinary toxicity in prostate cancer patients undergoing external beam radiotherapy (EBRT).

Main Methods:

Phase 2 clinical trial involving 28 patients with nonmetastatic prostate cancer.
Patients receive external beam radiotherapy (EBRT) alone, with doses from 70-80 Gy.
A mobile app prompts patients to drink 300 ml of water before each radiotherapy session.

Main Results:

Recruitment is scheduled from March 2025 to October 2026.
The study is expected to conclude in December 2026.
This trial is the first to investigate a reminder app's effect on bladder volume during prostate cancer radiotherapy.

Conclusions:

A mobile app may improve patient adherence to hydration protocols.
This intervention has the potential to reduce urinary toxicity associated with prostate cancer radiotherapy.
Further results are pending study completion in December 2026.