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Exploring the biological functions and disease implications of OSGINs: A journey from discovery to clinical relevance

Qian-Fei Cui1, Chong Liu1, Xue-Man Dong2

  • 1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.

Biochemical Pharmacology
|April 8, 2025
PubMed

Insights

Oxidative stress-induced growth inhibitors (OSGINs) are a new protein class regulating cell processes and disease. This review synthesizes OSGIN research and identifies potential drug targets.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Oxidative stress-induced growth inhibitors (OSGINs) are emerging proteins involved in redox balance.
  • OSGINs regulate critical cellular processes like proliferation, autophagy, apoptosis, and ferroptosis.
  • Their dysregulation is linked to diseases including cancer, atherosclerosis, and pulmonary fibrosis.

Purpose of the Study:

  • To provide a systematic review of current OSGIN research.
  • To elucidate the molecular functions, regulatory mechanisms, disease roles, and environmental influences on OSGINs.
  • To identify potential therapeutic strategies targeting OSGINs.

Main Methods:

  • Systematic literature review of OSGINs.
  • Analysis of molecular functions and regulatory pathways.
  • Virtual screening for potential OSGIN inhibitors.

Main Results:

  • OSGINs play significant roles in cellular homeostasis and disease pathogenesis.
  • Environmental factors and compounds can modulate OSGIN expression and activity.
  • Identification of novel small molecules with potential inhibitory effects on OSGINs.

Conclusions:

  • OSGINs are crucial regulators of cellular processes with implications in various diseases.
  • Targeting OSGINs presents a promising avenue for therapeutic intervention.
  • This review offers insights for future research and drug development concerning OSGINs.
Keywords:
Environmental stressorsOKL38OSGINsOxidative stressTherapeutic targets

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