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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

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Risk factors, clinical characteristics, and outcomes of perinatal stroke in a Tertiary University Hospital

Shaden S Alfayez1, Muddathir H Hamad1, Amal Y Kentab1

  • 1From the Division of Neurology (Alfayez, Hamad, Kentab, Alanezi, Kurdi, Bashiri), Department of Pediatrics, College of Medicine, King Saud University Medical City, King Saud University, and from the Department of Pediatrics (Almuhideb), King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)
|April 8, 2025
PubMed
Abstract

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A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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