The bone growing concept: A call for a paradigm shift in bone reconstruction.

Area of Science:

• Oral surgery
• Biomaterials science
• Regenerative medicine

Background:

• Alveolar bone reconstruction evolved from bone transfer to regeneration to improve outcomes and reduce morbidity.
• Current regeneration techniques are lengthy and provide suboptimal biological results due to reliance on inert bone substitutes.
• The limited supply of endogenous cells and growth factors hinders optimal bone regeneration.

Purpose of the Study:

• To propose a novel biological approach for alveolar bone reconstruction.
• To enhance bone regeneration by incorporating exogenous cells and growth factors.
• To introduce a biomorphometric algorithm for personalized treatment of bone defects.

Main Methods:

• Review of current alveolar bone reconstruction techniques.
• Proposal of a new paradigm incorporating exogenous cells and growth factors.
• Development of a biomorphometric clinical algorithm.

Main Results:

• Current methods are prolonged and yield suboptimal biological results.
• A biological approach with exogenous cells and growth factors promises enhanced bone growth.
• A biomorphometric algorithm can tailor treatment protocols.

Conclusions:

• A paradigm shift towards biological approaches is necessary for improved alveolar bone regeneration.
• Incorporating exogenous cells and growth factors can overcome limitations of current techniques.
• Personalized treatment algorithms are crucial for optimizing bone regeneration outcomes.