Predictive model development for left atrial remodeling in hypertrophic cardiomyopathy.

Area of Science:

• Cardiology
• Cardiovascular Imaging
• Clinical Risk Prediction

Background:

• Left atrial structural remodeling significantly impacts hypertrophic cardiomyopathy (HCM) patient prognosis.
• Early identification of left atrial remodeling is crucial for timely intervention.

Purpose of the Study:

• To investigate clinical characteristics and risk factors for left atrial remodeling in HCM patients.
• To develop and validate an early prediction model for left atrial remodeling in HCM.

Main Methods:

• Retrospective analysis of 1554 hospitalized HCM patients undergoing echocardiography.
• Classification into remodeling (left atrial diameter ≥ 40 mm) and control groups.
• Multivariate logistic regression and nomogram construction for risk prediction.

Main Results:

• Identified prothrombin time, main pulmonary artery diameter, left ventricular ejection fraction, and interventricular septal thickness as independent predictors.
• The developed nomogram showed good discriminatory power (AUC 0.7328) and accurate calibration.
• These factors collectively predict left atrial remodeling in HCM patients.

Conclusions:

• Prothrombin time, main pulmonary artery diameter, left ventricular ejection fraction, and interventricular septal thickness are significant risk factors for left atrial remodeling in HCM.
• The nomogram serves as a valuable tool for early risk stratification and management optimization.
• Early detection of left atrial remodeling can improve patient outcomes in HCM.