Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study identified seven urinary metabolites as noninvasive biomarkers for colorectal polyps (CRPs). A diagnostic nomogram using these metabolites showed high accuracy for early CRP detection.
Area Of Science
- Metabolomics
- Biomarker Discovery
- Colorectal Cancer Prevention
Background
- Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC).
- Early detection of CRPs is crucial for CRC prevention.
- Current diagnostic methods are invasive, necessitating noninvasive biomarkers.
Purpose Of The Study
- To identify urinary metabolite biomarkers for diagnosing CRPs.
- To develop a diagnostic nomogram based on noninvasive urinary metabolite screening.
Main Methods
- Urine samples from 192 participants (64 CRP patients, 128 controls) were analyzed using GC-MS and UPLC-MS.
- Metabolite screening involved WGCNA, LASSO, and SVM-RFE.
- A diagnostic nomogram was constructed and validated using ROC curves, calibration plots, and DCA.
Main Results
- Seven key urinary metabolites were significantly associated with CRP.
- Saccharin and N-omega-acetylhistamine were identified as risk factors; N-methyl-L-proline, trimethylsilyl ester as a protective factor.
- The nomogram achieved high discriminatory power (AUC 0.974 training, 0.960 validation) and demonstrated clinical utility.
Conclusions
- Seven urinary metabolites serve as potential noninvasive biomarkers for CRP.
- The developed diagnostic nomogram exhibits high predictive accuracy and clinical applicability.
- This approach offers a promising tool for the early detection of colorectal polyps.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
