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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and

Yang Xie1,2, Yiyi Jin2, Zide Liu2

  • 1Department of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, Jiangxi, China.

Cancer Medicine
|April 9, 2025
PubMed
Summary

This study identified seven urinary metabolites as noninvasive biomarkers for colorectal polyps (CRPs). A diagnostic nomogram using these metabolites showed high accuracy for early CRP detection.

Keywords:
colorectal polypmachine learningnomogramurine metabolomics

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Area of Science:

  • Metabolomics
  • Biomarker Discovery
  • Colorectal Cancer Prevention

Background:

  • Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC).
  • Early detection of CRPs is crucial for CRC prevention.
  • Current diagnostic methods are invasive, necessitating noninvasive biomarkers.

Purpose of the Study:

  • To identify urinary metabolite biomarkers for diagnosing CRPs.
  • To develop a diagnostic nomogram based on noninvasive urinary metabolite screening.

Main Methods:

  • Urine samples from 192 participants (64 CRP patients, 128 controls) were analyzed using GC-MS and UPLC-MS.
  • Metabolite screening involved WGCNA, LASSO, and SVM-RFE.
  • A diagnostic nomogram was constructed and validated using ROC curves, calibration plots, and DCA.

Main Results:

  • Seven key urinary metabolites were significantly associated with CRP.
  • Saccharin and N-omega-acetylhistamine were identified as risk factors; N-methyl-L-proline, trimethylsilyl ester as a protective factor.
  • The nomogram achieved high discriminatory power (AUC 0.974 training, 0.960 validation) and demonstrated clinical utility.

Conclusions:

  • Seven urinary metabolites serve as potential noninvasive biomarkers for CRP.
  • The developed diagnostic nomogram exhibits high predictive accuracy and clinical applicability.
  • This approach offers a promising tool for the early detection of colorectal polyps.