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Area of Science:

  • Biomedical Science
  • Pharmacology
  • Angiogenesis Research

Background:

  • Angiogenesis is crucial for tumor progression and wound healing.
  • Pomegranate (Punica granatum, PG) extracts are investigated for their angiogenic effects.

Purpose of the Study:

  • To systematically review PG extracts' anti-angiogenic effects in cancer models.
  • To review PG extracts' pro-angiogenic effects in chronic wound healing (CWH) models.

Main Methods:

  • Systematic review following PRISMA guidelines.
  • Searched PubMed, Scopus, and Google Scholar for preclinical studies.
  • Included 14 studies (10 cancer, 4 CWH).

Main Results:

  • In cancer models, PG extracts reduced vascular endothelial growth factor (VEGF) and endothelial tube formation.
  • In CWH models, topical PG peel extract enhanced VEGF and wound closure.
  • Mechanisms involve peroxisome proliferator-activated receptor pathways and PG polyphenols.

Conclusions:

  • PG extracts exhibit dual angiogenic properties, inhibiting cancer and promoting wound healing.
  • Further research needed on standardization, molecular mechanisms, and clinical translation.
  • PG extracts represent a promising therapeutic strategy for angiogenesis modulation.