Correlation between estimated glucose disposal rate and diabetic depression: a population-based study
Xiangzhi Shao1, Huifang Dai2, Lielie Zhu1
1Department of Rehabilitation, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, China.
Lower insulin resistance, measured by estimated glucose disposal rate (eGDR), is linked to reduced depression risk in diabetes mellitus (DM) patients. Leukocytes and neutrophils partially mediate this association.
Area of Science:
- Endocrinology and Metabolism
- Psychiatry and Mental Health
- Public Health and Epidemiology
Background:
- Growing evidence links depression with insulin resistance (IR).
- Insulin resistance (IR) is a metabolic dysfunction associated with type 2 diabetes.
- Depression is a common comorbidity in patients with diabetes mellitus (DM).
Purpose of the Study:
- To investigate the association between estimated glucose disposal rate (eGDR), a practical measure of IR, and depression.
- To explore the role of leukocytes and neutrophils as potential mediators in the eGDR-depression relationship.
Main Methods:
- Cross-sectional analysis of 3,080 adults with DM from NHANES 1999-2018.
- Multivariate logistic regression, restricted cubic spline (RCS) analysis, and mediation analysis were employed.
- Subgroup analyses examined associations across diverse demographic and clinical characteristics.
Main Results:
- A significant inverse linear correlation was found between eGDR and depression in DM patients (OR=0.89).
- Higher eGDR quartiles (Q3, Q4) were associated with significantly reduced depression risk (28% and 54% lower, respectively) compared to Q1.
- Leukocytes (4.0%) and neutrophils (3.6%) partially mediated the relationship between eGDR and depression.
Conclusions:
- This study confirms a significant inverse linear correlation between eGDR and depression prevalence in patients with DM.
- Leukocytes and neutrophils are identified as significant mediating factors in the association between insulin resistance and depression.
- Findings highlight the potential clinical relevance of monitoring IR and associated inflammatory markers in diabetic patients with depression.
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