Related Experiment Video
Updated: May 15, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Non-coding RNAs as key regulators of epithelial-mesenchymal transition in breast cancer
Jing Peng1, Wenhui Liu1, Jiaju Tian1
1The First Clinical Medical College, Lanzhou University, Lanzhou, China.
Abstract:
This study examines the critical role of non-coding RNAs (ncRNAs) in regulating epithelial-mesenchymal transition (EMT) in breast cancer, a prevalent malignancy with significant metastatic potential. EMT, wherein cancer cells acquire mesenchymal traits, is fundamental to metastasis. ncRNAs-such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)-modulate EMT by influencing gene expression and signaling pathways, affecting cancer cell migration and invasion. This review consolidates recent findings on ncRNA-mediated EMT regulation and explores their diagnostic and therapeutic potential. Specifically, miRNAs inhibit EMT-related transcription factors, while lncRNAs and circRNAs regulate gene expression through interactions with miRNAs, impacting EMT progression. Given the influence of ncRNAs on metastasis and therapeutic resistance, advancing ncRNA-based biomarkers and treatments holds promise for improving breast cancer outcomes.
Related Concept Videos
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
lncRNA - Long Non-coding RNAs
MicroRNAs
Master Transcription Regulators
Regulation of Expression at Multiple Steps
Epigenetic Regulation

