Related Experiment Video
Updated: May 15, 2025
Subjective Refraction Test Using a Smartphone for Vision Screening
Published on: October 18, 2024
One-year changes in axial length and refraction in children using low-level red light and distant-image screen for
Ke Yang1, Yuhan Wang1, Xiaoxia Li2
1Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Objective:
To assess the efficacy and safety of 650-nm low-level red light (RL) and distant-image therapy (DIT) for myopia.
Methods:
A randomized clinical trial. Children aged 8-10 years with a spherical equivalent error (SER) ranging from -1 to -1.5 diopters (D) were enrolled, and were randomly allocated to the following group: RL, DIT, RL + DIT, and control in a 1:1:1:1 ratio. The primary outcomes were changes in SER and axial length (AL).
Results:
One hundred and sixteen children randomized, girls accounted for 45.69% (53/116). The median one-year changes in SER were 0.21D (inter-quartile range, IQR: -0.03D to 0.46D), -0.06D (-0.32D to 0.19D), -0.08D (-0.31D to 0.14D), and -0.30D (-0.51D to -0.09D), respectively, for the RL + DIT, RL, DIT, and the control group. The median one-year changes in AL were 0.04 mm (-0.03 mm to 0.13 mm), 0.05 mm (-0.03 mm to 0.14 mm), 0.30 mm (0.22 mm to 0.37 mm), and 0.42 mm (0.35 mm to 0.49 mm), respectively, for the RL + DIT, RL, DIT, and the control group. Fundus photographs revealed no retinal changes across all groups.
Conclusion:
Participants who underwent daily 650-nm low-level red light therapy combined with distant-image screen intervention for 12 months demonstrated a significant deceleration in myopia progression, with 79.3% exhibiting potential for reversal of myopia. No safety concerns were identified through OCT and fundus photography.
Clinical Trial Registration:
ClinicalTrials.gov, NCT06683287.
