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Updated: May 15, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

503

Imaging findings of thyroid diseases in children

Yuko Tsujioka1, Yoshitake Yamada1, Tomonobu Hasegawa2

  • 1Department of Radiology, Keio University School of Medicine, Tokyo, Japan.

Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology
|April 9, 2025
PubMed

Insights

Imaging plays a crucial role in diagnosing pediatric thyroid diseases, especially congenital hypothyroidism. Ultrasonography and scintigraphy are key tools for assessing thyroid structure and function, guiding timely medical intervention.

Area of Science:

  • Pediatric Endocrinology
  • Radiology
  • Nuclear Medicine

Background:

  • Prompt diagnosis of pediatric thyroid diseases is essential for timely intervention.
  • Congenital hypothyroidism is a critical pediatric emergency requiring rapid assessment.
  • Various imaging modalities aid in evaluating thyroid morphology, function, and pathology in children.

Purpose of the Study:

  • To review essential imaging findings in pediatric thyroid diseases.
  • To highlight the role of imaging in diagnosing conditions like congenital hypothyroidism and thyroid dysgenesis.
  • To discuss the utility and limitations of different imaging techniques.

Main Methods:

  • Review of imaging findings in pediatric thyroid diseases.
  • Discussion of ultrasonography for thyroid morphology and dysgenesis.
  • Evaluation of 123I-scintigraphy and 99mTc-pertechnetate scintigraphy for iodine metabolism, hormone synthesis, and tissue delineation.

Main Results:

  • Ultrasonography is primary for assessing thyroid morphology and dysgenesis.
  • 123I-scintigraphy assesses iodine metabolism; perchlorate discharge test aids in diagnosing dyshormonogenesis.
  • 99mTc-pertechnetate scintigraphy is sensitive for delineating thyroid tissue with low radiation exposure, aiding dysgenesis diagnosis.

Conclusions:

  • Imaging is critical for diagnosing pediatric thyroid diseases, particularly congenital hypothyroidism.
  • Ultrasonography and scintigraphy (99mTc-pertechnetate) are valuable tools for evaluating thyroid structure and function.
  • Understanding imaging characteristics aids in timely diagnosis and management of pediatric thyroid conditions.

Keywords:
pediatric thyroid diseasethyroid dysgenesisthyroid dyshormogenesisthyroid imagingthyroiditis

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