Related Experiment Video
Updated: May 15, 2025
07:35
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
1.5K
Associations between APOE-TOMM40 '523 haplotypes and limbic system white matter microstructure
Katelyn E Mooney1,2, Derek B Archer3,4,5, Aditi Sathe3
1University of California Los Angeles, Neuroscience Interdepartmental Program (NSIDP), David Geffen School of Medicine Los Angeles California USA.
Alzheimer'S & Dementia (Amsterdam, Netherlands)
|April 9, 2025
Summary
The apolipoprotein E (APOE) gene and TOMM40-
Area of Science:
- Neuroimaging
- Genetics
- Aging Research
Background:
- The apolipoprotein E (APOE) gene is a key determinant of brain aging.
- The Translocase of Outer Mitochondrial Membrane 40 (TOMM40) gene, specifically the TOMM40-'523-S haplotype, may modify APOE's effects.
- Limbic white matter microstructure (WMM) is crucial for memory and cognition.
Purpose of the Study:
- To investigate the association between APOE-TOMM40-'523 haplotypes and WMM in limbic tracts.
- To examine these associations separately in non-Hispanic Black and White individuals.
- To determine if TOMM40-'523-S copy number influences WMM aging in a race-stratified manner.
Main Methods:
- Diffusion MRI was used to measure WMM metrics, including free-water (FW) and free-water-corrected fractional anisotropy (FAFWcorr).
- Linear regression models were applied, stratified by APOE genotype (ε4+ vs. ε3/ε3) and racialized group (Black vs. White).
- Associations between TOMM40-'523-S carrier status and WMM in key limbic tracts were assessed.
Main Results:
- In Black APOE ε4+ carriers, one copy of TOMM40-'523-S was associated with normal aging WMM metrics in the cingulum, uncinate fasciculus, fornix, and inferior longitudinal fasciculus.
- In White APOE ε3/ε3 carriers, two copies of TOMM40-'523-S were linked to abnormal aging WMM metrics in the cingulum and inferior temporal gyrus.
- Differential effects of TOMM40-'523-S on WMM were observed between racialized groups, suggesting a modifying role of APOE background.
Conclusions:
- The TOMM40-'523-S haplotype shows differential associations with white matter microstructure aging based on APOE genotype and racialized background.
- '523-S appears risk-mitigating for limbic WMM aging in Black APOE ε4+ carriers.
- Conversely, '523-S may be associated with abnormal aging WMM in White APOE ε3/ε3 carriers, supporting prior research.
Related Concept Videos
01:53Cause and Effect
10.8K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
10.8K
02:20Correlations
32.0K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
32.0K
01:27Correlation and Causation
37.2K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
37.2K
00:53Correlation and Regression
1.2K
In statistics, correlation describes the degree of association between two variables. In the subfield of linear regression, correlation is mathematically expressed by the correlation coefficient, which describes the strength and direction of the relationship between two variables. The coefficient is symbolically represented by 'r' and ranges from -1 to +1. A positive value indicates a positive correlation where the two variables move in the same direction. A negative value suggests a...
1.2K
02:01Factorial Design
12.7K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
12.7K
01:09Correlation
11.5K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
11.5K