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Mining and validating quorum sensing interference molecules from food-derived compounds for Salmonella Typhimurium
Hongrui Zhang1, Danlei Chen1,2, Peng Zhang1
1School of Chemical Engineering and Technology, Tianjin, University, Tianjin, 300350, China. jianjunq@tju.edu.cn.
Food & Function
|April 9, 2025
Summary
Researchers identified novel food-derived compounds that disrupt bacterial communication, offering potential new treatments against infections like Salmonella Typhimurium by weakening virulence and combating drug resistance.
Area of Science:
- Microbiology
- Computational Biology
- Drug Discovery
Background:
- Pathogenic infections, including Salmonella Typhimurium, pose significant health challenges.
- Food-derived compounds offer a promising source for novel therapeutic agents.
- Quorum sensing interference molecules (QSIMs) represent a potential strategy to combat bacterial virulence.
Purpose of the Study:
- To identify and characterize food-derived QSIMs targeting Salmonella Typhimurium.
- To evaluate the therapeutic potential of these compounds against bacterial infections.
- To explore mechanisms of action and challenges in developing these agents.
Main Methods:
- Structure-based virtual screening of over 8000 compounds from the FooDB database.
- Experimental validation using surface plasmon resonance (SPR) analysis.
- Assessment of QSIM effects on bacterial growth, biofilm formation, and motility.
Main Results:
- Identified potential QSIMs (skatole, 2-aminoquinoline, tricarballylic acid, L-3-phenyllactic acid) with high affinity for the LsrB receptor.
- Validated binding affinity using SPR analysis.
- Demonstrated effectiveness of QSIMs in inhibiting bacterial growth, biofilm formation, and motility.
Conclusions:
- Food-derived compounds can be effectively identified as QSIMs using integrated computational and experimental approaches.
- These identified QSIMs show promise in weakening bacterial virulence and reducing infection.
- Further development of food-derived QSIMs could offer solutions for combating drug-resistant pathogens.
