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Updated: May 15, 2025

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

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Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine

Mohamed O Kamileen1,2, Benke Hong1,3, Klaus Gase1

  • 1Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, D-07745, Jena, Germany.

Angewandte Chemie (International Ed. in English)
|April 9, 2025
PubMed
Summary

Plants use enzymes to create diverse chemical structures from intermediates like 19E-geissoschizine. Three cytochrome P450 enzymes in Catharanthus roseus transform this intermediate into four distinct alkaloid scaffolds, showcasing enzymatic versatility.

Keywords:
BiosynthesisEnzymesGeissoschizineNatural productsPlant P450s

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