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Updated: May 15, 2025

Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle
Published on: December 1, 2023
Exploring mitochondrial dynamics and localization under cellular stress: A comprehensive insight
Saloni Agarwal1, Kavikumar Angamuthu Karuppusamy, Abhishek K Gupta
1Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Abstract:
Within a cell, the mitochondrion serves various functions, including ATP synthesis, generation of reactive oxygen species, maintenance of iron and calcium ion homeostasis, and apoptosis, all of which are essential for the cell's function. Recent studies have highlighted the significance of mitochondrial dynamics and spatial distribution in ensuring proper mitochondrial function and cell survival, particularly under various cellular stress conditions. Mitochondrial dynamics include various processes such as mitochondrial fission and fusion, mitophagy, mitochondrial biogenesis, and mitochondrial transport. This review article explores the impact of cellular stressors on mitochondrial dynamics and distribution. It also sheds light on the critical role of stress-induced alterations in mitochondrial dynamics and distribution from the perspective of cell survival.
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