Comprehensive review of leonurine: harnessing its therapeutic potential for chronic diseases

Chronic diseases (CD) pose a significant global health challenge, affecting millions of individuals and contributing to substantial morbidity, mortality, and healthcare burden. Therapeutic approaches primarily aim at symptom management through pharmacotherapy, lifestyle modifications, dietary interventions, and regular physical activity. Given the persistent challenge of limited treatment options, scientific research has increasingly focused on exploring natural compounds for their therapeutic potential. Leonurine, a natural compound first isolated from the plant Herba leonuri in 1930, has garnered significant attention due to its extensive pharmacological properties relevant to the treatment of CDs. Extensive studies over the past have revealed that leonurine exhibits anticancer, antidiabetic, anti-inflammatory, and antioxidant activities. These effects are mediated through the modulation of various signaling pathways, including the TGF-β/Smad2, Nrf-2, JNK, NF-κB, BDNF/TrkB/CREB, TLR4/NF-κB/TNF-α, ATF4/CHOP/ASCL4, Akt, HIF-1, SHH/GLI, and mTOR/ERK, whose dysregulation is implicated in the pathogenesis of various CDs. Furthermore, leonurine regulates the levels of multiple pro-inflammatory cytokines, including numerous interleukins and TNF-α, indicating its potential in treating a wide range of chronic conditions, including cardiovascular, neurological, skeletal, and renal diseases. This review seeks to present an in-depth analysis of leonurine's therapeutic potential, emphasizing its promise in the management of various CDs. It also outlines potential avenues for future research to fully harness its pharmacological advantages in treating these conditions.