Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

342
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
342
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

159
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
159
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

32
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
32

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The past, present, and future of Alzheimer's disease-part 3: the future.

Arquivos de neuro-psiquiatria·2026
Same author

Testosterone abuse in Brazil: a growing public health challenge.

Clinics (Sao Paulo, Brazil)·2026
Same author

Regional mapping of CSF1R-positive microglia in neurodegenerative diseases and progressive MS, with exploratory presynaptic marker analyses.

Journal of neuroinflammation·2026
Same author

FTLD-TDP versus LATE-NC: Experience of a Brain Bank specializing in FTLD-TDP.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

IgG4-related inflammatory pseudotumor presenting with refractory seizures: a diagnostic pitfall.

Arquivos de neuro-psiquiatria·2026
Same author

Bridging the gap: estimates of undetected dementia in Brazil.

Age and ageing·2026

Related Experiment Video

Updated: May 15, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.6K

Association Between Alcohol Consumption, Cognitive Abilities, and Neuropathologic Changes: A Population-Based Autopsy

Alberto Fernando Oliveira Justo1,2, Regina Paradela1,2, Natalia Gomes Goncalves2

  • 1Physiopathology in Aging Laboratory (LIM-22), Department of Pathology, University of São Paulo Medical School, Brazil.

Neurology
|April 9, 2025
PubMed
Summary

Heavy alcohol consumption is linked to brain changes and cognitive decline, particularly in former heavy drinkers. Hyaline arteriolosclerosis fully mediates the relationship between alcohol intake and impaired cognitive abilities.

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.4K
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.3K

Related Experiment Videos

Last Updated: May 15, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.6K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.4K
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.3K

Area of Science:

  • Neurology
  • Gerontology
  • Public Health

Background:

  • Heavy alcohol consumption poses significant global health risks, contributing to increased morbidity and mortality.
  • The long-term effects of excessive alcohol intake on cognitive function and dementia-related brain changes remain incompletely understood.

Purpose of the Study:

  • To investigate the association between alcohol consumption patterns and age-related neuropathological outcomes.
  • To analyze the impact of alcohol on cognitive abilities and brain mass in an aging population.

Main Methods:

  • A cross-sectional autopsy study involving 1,781 participants.
  • Classification of alcohol consumption into never, moderate, heavy, and former heavy drinkers.
  • Evaluation of neuropathology (Alzheimer's, Lewy body, TDP-43, vascular changes) and cognitive function (CDR-SB), with mediation analysis.

Main Results:

  • Moderate, heavy, and former heavy drinking were associated with hyaline arteriolosclerosis.
  • Heavy and former heavy drinking correlated with neurofibrillary tangles.
  • Former heavy drinking linked to reduced brain mass and poorer cognitive abilities, fully mediated by hyaline arteriolosclerosis.

Conclusions:

  • Alcohol consumption, particularly heavy and former heavy use, is associated with specific neuropathologies like hyaline arteriolosclerosis and neurofibrillary tangles.
  • Former heavy alcohol consumption negatively impacts brain mass and cognitive function.
  • Hyaline arteriolosclerosis plays a crucial role in mediating the detrimental effects of alcohol on cognition.