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Related Experiment Video

Updated: May 15, 2025

Studying Cavitation Enhanced Therapy
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Passive cavitation mapping for biomedical applications using higher order delay multiply and sum beamformer with

Christian Marinus Huber1, Nicole Dorsch2, Helmut Ermert3

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Professorship for AI-Controlled Nanomaterials (KINAM), Universitätsklinikum Erlangen, Glücksstrasse 10a, Erlangen, 91054, Bavaria, Germany; Institute of Microwaves and Photonics (LHFT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Cauerstrasse 9, Erlangen, 91058, Bavaria, Germany.

Ultrasonics
|April 9, 2025
PubMed
Summary

This study introduces a novel nonlinear beamforming method for enhanced ultrasound cavitation monitoring. The Delay Multiply and Sum (DMAS) technique improves resolution and image quality for safer biomedical therapies.

Keywords:
BeamformingBiomedical ultrasoundCavitation mappingDelay multiply and sumPassive ultrasound imaging

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Area of Science:

  • Biomedical Engineering
  • Acoustics
  • Medical Imaging

Background:

  • Ultrasound-induced cavitation is vital for therapies like drug delivery, sonoporation, and tumor ablation.
  • Accurate monitoring of cavitation dose and location is crucial for therapy safety and efficacy.
  • Current passive cavitation mapping (PCM) methods using Delay and Sum (DAS) or Robust Capon Beamformer (RCB) have limitations in resolution and computational cost.

Purpose of the Study:

  • To develop an advanced beamforming technique for improved passive cavitation mapping.
  • To enhance the resolution and accuracy of cavitation monitoring in biomedical ultrasound applications.

Main Methods:

  • Proposed a higher-order nonlinear Delay Multiply and Sum (DMAS) beamformer.
  • Implemented DMAS with linear complexity using determinants from symmetrical polynomials.
  • Validated the method through simulations and experimental studies.

Main Results:

  • The DMAS beamformer significantly improved axial and lateral point spread function resolution.
  • Demonstrated enhanced image quality in passive cavitation mapping.
  • Achieved linear complexity, making the method computationally efficient.

Conclusions:

  • The higher-order nonlinear DMAS beamformer offers superior performance for passive cavitation mapping.
  • This advancement promises more accurate and reliable cavitation monitoring in diverse biomedical applications.
  • The method addresses the limitations of conventional beamforming techniques.