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Updated: May 15, 2025

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
Published on: April 15, 2015
Scaling up neuronal Ca2+, signaling on ER ladders
1Ca2+ signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar; Department of Physiology and Biophysics, Weill Cornell Medicine, NY, USA.
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Dendritic Ca2+ signaling is critical for neural transmission and signal processing, however the detailed molecular mechanisms have not been elucidated. Using elegant and complementary imaging approaches Benedetti et al. discover a distinctive ER ladder architecture in dendrites and show that precise localization of Ca2+ signaling proteins at endoplasmic reticulum (ER)-plasma membrane (PM) junctions supports integration of Ca2+ signaling along the dendrite.

