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Osteoporosis and multiple sclerosis: Exploring the complex intersection between bone and brain, a clarion call for change

  • 0Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States.
Multiple Sclerosis and Related Disorders +

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April 9, 2025

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April 9, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Osteoporosis is common in people with multiple sclerosis (PwMS), increasing fracture risk. Early identification and management strategies are crucial for improving outcomes in this population.

Area Of Science

  • Neurology
  • Endocrinology
  • Bone Metabolism

Background

  • Osteoporosis is prevalent and often overlooked in people with multiple sclerosis (PwMS).
  • It manifests more frequently and at a younger age in PwMS than in the general population.
  • Reduced bone mineral density (BMD) significantly elevates fracture risk in PwMS.

Purpose Of The Study

  • To review key risk factors for osteoporosis in PwMS.
  • To explore shared inflammatory pathways between multiple sclerosis (MS) and osteoporosis.
  • To discuss strategies for early detection and proactive management of osteoporosis in PwMS.

Main Methods

  • Literature review identifying risk factors.
  • Analysis of shared inflammatory mechanisms.
  • Synthesis of current management and intervention strategies.

Main Results

  • Identified risk factors include age, vitamin D deficiency, reduced mobility, and corticosteroid use.
  • Shared inflammatory processes, like elevated pro-inflammatory cytokines, contribute to bone loss in MS.
  • Early detection and management are vital for mitigating fracture risk.

Conclusions

  • Comprehensive management strategies are essential for osteoporosis in PwMS.
  • Tailored pharmacological treatments and interventions are needed.
  • Addressing osteoporosis improves overall outcomes for people with MS.

Keywords:

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