Related Experiment Video
Updated: Aug 10, 2026

05:40
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
Parental alcoholism in opioid addicts
The Journal of Nervous and Mental Disease
|August 1, 1985
Summary
Parental alcoholism increases the risk of alcoholism, depression, and antisocial personality disorder in opioid addicts. Disruptive childhood events did not significantly worsen these conditions independently.
Area of Science:
- Psychiatry
- Genetics
- Addiction Medicine
Background:
- Parental alcoholism is a known risk factor for various psychiatric disorders.
- Understanding the familial transmission of addiction and co-occurring disorders is crucial for effective treatment.
Purpose of the Study:
- To investigate the relationship between parental alcoholism and the prevalence and severity of alcoholism, depression, and antisocial personality disorder in opioid addicts.
- To examine the independent and additive effects of disruptive childhood events and parental alcoholism on these disorders.
Main Methods:
- The family history method was employed.
- Data were collected from 638 opioid addicts.
- Relationships between parental alcoholism and co-occurring disorders were analyzed.
Main Results:
- Opioid addicts with a parental history of alcoholism showed higher rates of concurrent alcoholism, depression, and antisocial personality disorder.
- Parental alcoholism was associated with more severe alcohol abuse problems and more disruptive childhood events.
- Disruptive childhood events did not significantly exacerbate the severity of alcohol-related problems, depression, or antisocial behaviors.
Conclusions:
- Parental alcoholism is a significant risk factor for multiple psychiatric disorders in opioid addicts.
- Findings align with some aspects of "familial alcoholism" but highlight unique characteristics in opioid-addicted populations.
- The study underscores the complex interplay of genetic and environmental factors in addiction.
More Related Videos
Related Concept Videos
Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Drug Abuse and Addiction: Pharmacological Phenomena
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
CNS Depressants: Alcohol and Nicotine
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

