Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of immunosuppressive and biological drugs in patients with asymptomatic monoclonal gammopathies (MGUS or smoldering myeloma) and concomitant autoimmune disorders: Results from the real-life MUSA study.

British journal of haematology·2026

Same author

Leukemic architecture as a framework for risk stratification in NPM1-mutated acute myeloid leukemia.

Discover oncology·2026

Same author

CTNNB1 Mutations in Non-small Cell Lung Cancer: Clinicopathological Characteristics of a Small Cohort.

Anticancer research·2026

Same author

Integrated Epithelial Models Reveal Anti-Inflammatory and Barrier Modulatory Properties of Ozoile in Inflammatory Bowel Disease.

Antioxidants (Basel, Switzerland)·2026

Same author

Ferroptosis as a Therapeutic Vulnerability to Overcome Chemoresistance in Gastric Cancer.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Chimeric Antigen Receptor-T Cells Fate after Infusion: Cellular Kinetics and Molecular Monitoring.

Transplantation and cellular therapy·2026

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

The role of the tumor microenvironment and inflammatory pathways in driving drug resistance in gastric cancer: A

Francesco Albano¹, Francesca Lospinoso Severini², Giovanni Calice²

¹Department of Biology, University of Naples Federico II, Naples, Italy.

Biochimica Et Biophysica Acta. Molecular Basis of Disease

|April 9, 2025

Summary

The tumor microenvironment (TME) in gastric cancer (GC) promotes chemoresistance and progression. Targeting inflammatory pathways and specific immune cells like TAMs and Tregs offers strategies to improve chemotherapy response.

Keywords:

Cytokines Drug resistance Gastric cancer Immune cells Inflammation Tumor microenvironment

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Related Experiment Videos

Last Updated: Jun 19, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Area of Science:

Oncology
Immunology
Cancer Biology

Background:

The tumor microenvironment (TME) is crucial in gastric cancer (GC) progression and chemotherapy resistance.
Chronic inflammatory pathway activation is a key event in gastric tumorigenesis.
Immune cells within the TME interact with cancer cells, creating an immunosuppressive environment that impacts treatment efficacy.

Purpose of the Study:

To explore the role of the TME and inflammatory pathways in gastric cancer.
To identify strategies for enhancing patient response to chemotherapy.
To provide insights into TME cytotypes and their impact on GC chemoresistance.

Main Methods:

Systematic review and discussion of existing literature on TME, inflammation, and GC.
Analysis of immune cell infiltration and their interactions within the GC TME.
Examination of molecular signatures associated with TME components.

Main Results:

The TME significantly influences GC progression and reduces chemotherapy responsiveness.
Sustained inflammatory pathway activation is integral to gastric tumorigenesis.
Tumor-associated macrophages (TAMs) and regulatory T cells (Tregs) play critical roles in promoting GC chemoresistance.

Conclusions:

Understanding the TME and its inflammatory components is essential for improving GC treatment outcomes.
Targeting specific TME cytotypes, particularly TAMs and Tregs, presents a promising therapeutic strategy.
Modulating the inflammatory status of the TME could overcome chemoresistance in gastric cancer.