Related Experiment Video
Updated: May 15, 2025
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
14.1K
Multiple Basal Cell Carcinomas. Timeline and Underlying Risk Factors.
R Fernández-de-Misa1, M Montes-de-Oca2, I Loizate1
1Servicio de Dermatología, Complejo Hospitalario Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España.
Actas Dermo-Sifiliograficas
|April 9, 2025
Summary
Over half of basal cell carcinoma (BCC) patients develop multiple BCCs (mBCC). Identifying risk factors like being male or diagnosed between 50-80 can help predict mBCC development and timeframe.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Basal cell carcinoma (BCC) frequently recurs, with 29-53% of patients developing new lesions.
- Understanding the development of multiple BCCs (mBCC) is crucial for patient management.
Purpose of the Study:
- To analyze the incidence and characteristics of patients developing more than one BCC.
- To define multiple BCC (mBCC) and identify associated risk factors.
- To determine the timeframe for mBCC development.
Main Methods:
- Retrospective observational study of 758 patients diagnosed with sporadic BCC between 2014-2014.
- Data collected included BCC dates, gender, age, histology, and initial presentation (cluster+).
- mBCC defined as developing BCCs exceeding the 75th percentile (3 lesions).
Main Results:
- Median follow-up of 100 months revealed 52.8% of patients developed more than one BCC.
- Risk factors for mBCC included initial cluster presentation (OR 5.6), male gender (OR 3.1), and first BCC diagnosis between ages 50-80 (OR 2.1).
- After 5 years, 54% of patients with these three factors developed mBCC; median time to mBCC was 38 months.
Conclusions:
- A quarter of patients with one BCC develop four or more.
- Routine clinical parameters can identify high-risk individuals for mBCC.
- Predicting the timeframe for mBCC development is possible using these factors.
Related Concept Videos
01:30Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
02:21Cancers Originate from Somatic Mutations in a Single Cell
11.3K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.3K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
02:18Cancer
47.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
47.2K
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K