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Nondisjunction

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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Related Experiment Video

Updated: Apr 30, 2026

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
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Factors Predicting Poor Outcomes Following Cranioplasty: A Single Center Analytical Study.

Mangalkumar Girish Rachatte1, Soumya Pahari2, Anil Pande3

  • 1Department of Neurosurgery, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India.

World Neurosurgery
|April 9, 2025
PubMed
Summary

Patient age, dominant lobe injury, and surgical factors like material used for cranioplasty (CP) predict poor outcomes. Initial neurological status does not significantly impact recovery after CP following decompressive craniectomy (DC).

Keywords:
ComplicationsCranioplastyDecompressive craniectomyTreatment outcome

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Area of Science:

  • Neurosurgery
  • Neurology
  • Reconstructive Surgery

Background:

  • Cranioplasty (CP) is a common procedure following decompressive craniectomy (DC).
  • Predicting outcomes after CP is crucial for patient management and surgical planning.
  • Factors influencing recovery post-CP require further investigation.

Purpose of the Study:

  • To identify predictors of poor outcomes after cranioplasty (CP).
  • To analyze the influence of preoperative patient characteristics and procedural factors on functional recovery.

Main Methods:

  • A cross-sectional follow-up study of 80 patients undergoing CP after DC.
  • Poor outcome defined as modified Rankin Scale (mRS) ≥3 at 6 months.
  • Univariate and binary logistic regression analyses were employed to identify predictors.

Main Results:

  • 55% of patients experienced poor outcomes (mRS ≥3) at 6 months post-CP.
  • Significant predictors of poor outcomes included older age, dominant lobe injury, post-decompressive craniectomy complications, non-autologous skull flap material, and non-cosmetic indications for CP.
  • Initial Glasgow Coma Scale score was not a predictor of poor outcome.

Conclusions:

  • Preoperative patient factors (age, injury type) and surgical factors (material, indication) significantly influence cranioplasty outcomes.
  • Long-term functional recovery is more dependent on patient-specific characteristics and surgical considerations than on the initial neurological status.