[PORK-CAT SYNDROME WITH ALLERGIC SYMPTOMS DUE TO THE INGESTION OF COW'S MILK]

Area of Science:

• Allergology
• Immunology
• Pediatrics

Background:

• Pork-cat syndrome (PCS) is an allergic condition characterized by reactions to mammalian meat, often linked to cat allergy.
• Symptoms can include urticaria and gastrointestinal distress, typically appearing after consuming specific meats.

Purpose of the Study:

• To present a pediatric case of pork-cat syndrome (PCS).
• To investigate the immunological mechanisms underlying cross-reactivity between cat allergens and food proteins.

Main Methods:

• Antigen-specific IgE testing for various allergens including cat dander, pork, beef, and milk.
• Skin prick testing with raw and heated food allergens.
• Immunoblot analysis and inhibition tests to confirm cross-reactivity.

Main Results:

• The patient exhibited high IgE levels against cat and dog dander, pork, beef, and milk.
• Skin reactions to raw pork, beef, and milk were heat-labile, suggesting protein denaturation.
• Immunoblotting confirmed IgE binding to a 67kDa protein in pork, identical in molecular weight to a cat allergen, confirming cross-reactivity.

Conclusions:

• This case demonstrates PCS in a child with delayed onset of milk allergy symptoms.
• Cross-reactivity between cat allergens (Fel d 1, Fel d 2) and proteins in pork (Sus s 1), beef (Bos d 6), and milk is a key feature of PCS.
• Cat ownership can contribute to sensitization to milk, extending beyond typical meat allergies in PCS patients.