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T1 Mapping-Derived Parameters in Breast Lesions: Diagnostic Accuracy and Correlation with Pathologic Features.

Shanshan Sun1, Shouju Wang2, Yuxia Tang2

  • 1Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, NO. 300, Guangzhou Road, Nanjing, Jiangsu 210029, China (S.S., S.W., Y.T., K.L., Y.S., F.W., Y.J.).

Academic Radiology
|April 9, 2025
PubMed
Summary

T1 mapping parameters, including extracellular volume fraction (ECV), effectively distinguish benign from malignant breast tumors. These T1 parameters also correlate with prognostic indicators in invasive breast cancer, aiding in predicting tumor invasiveness.

Keywords:
Breast cancerExtracellular volume fractionMagnetic resonance imagingT1 mapping

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Accurate differentiation between benign and malignant breast lesions is crucial for effective patient management.
  • Quantitative magnetic resonance imaging (MRI) techniques offer potential for non-invasive tumor characterization.

Purpose of the Study:

  • To assess the diagnostic capability of T1 mapping parameters in differentiating benign and malignant breast tumors.
  • To investigate the association between T1 mapping parameters and clinicopathologic prognostic indicators in invasive breast cancer.

Main Methods:

  • Prospective study including patients undergoing breast MRI with T1 mapping and apparent diffusion coefficient (ADC) measurements.
  • Comparison of T1 parameters (T10, T1c, ΔT1, ΔT1%, ECV) and ADC values between benign and malignant lesions.
  • Receiver operating characteristic (ROC) curve analysis for diagnostic performance and Spearman correlation for associations with prognostic factors in invasive ductal carcinoma (IDC).

Main Results:

  • Extracellular volume fraction (ECV) showed a high area under the curve (AUC) of 0.90, comparable to ADC (0.89).
  • A combined diagnostic model incorporating all parameters achieved the highest AUC of 0.95.
  • In IDC, ECV correlated positively with estrogen and progesterone receptor expression and negatively with Ki-67 expression.

Conclusions:

  • T1 mapping parameters, particularly ECV, demonstrate significant potential in distinguishing benign from malignant breast lesions.
  • T1 parameters may serve as valuable imaging biomarkers for predicting tumor invasiveness and correlating with prognostic indicators in invasive breast cancer.