Diabetic retinopathy: a comprehensive review of pathophysiology and emerging treatments

Diabetic retinopathy constitutes a major complication associated with diabetes mellitus, resulting in visual impairment and blindness on a global scale. The pathophysiology of DR is characterized by intricate interactions among metabolic, hemodynamic, and inflammatory pathways, which include the activation of the polyol pathway, the accumulation of advanced glycation end products, the overactivation of protein kinase C, dysregulation of the renin-angiotensin-aldosterone system, and retinal neurodegeneration. This review investigates the classification, complex pathophysiology, and therapeutic modalities for DR, encompassing conventional interventions such as anti-VEGF agents, aldose reductase inhibitors, angiotensin receptor blockers, laser photocoagulation, and vitrectomy. Innovative treatments, including advanced anti-VEGF agents, neuroprotective strategies, gene and stem cell therapies, and advancements in drug delivery systems, exhibit considerable transformative potential. Furthermore, integrating artificial intelligence for early detection and modulation of inflammatory pathways signifies cutting-edge progress in the field. By integrating contemporary knowledge and prospective avenues, this review underscores the significance of comprehending the multifaceted nature of DR and the advancements in its therapeutic approaches. The objective is to bridge the gaps between research findings and clinical application, thereby providing a comprehensive resource to enhance outcomes and quality of life for individuals impacted by DR.