Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

121
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
121
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

40 Hz audiovisual stimulation improves sustained attention and related brain oscillations.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

40 Hz Audiovisual Stimulation Improves Sustained Attention and Related Brain Oscillations.

bioRxiv : the preprint server for biology·2025
Same author

Sensory neurostimulation promotes stress resilience with frequency-specificity.

bioRxiv : the preprint server for biology·2025
Same author

Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice.

APL bioengineering·2025
Same author

40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Olfactory Training: Recommendation Frequency amongst Rhinologists.

International forum of allergy & rhinology·2025

Related Experiment Video

Updated: May 21, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.5K

Goal-specific hippocampal inhibition gates learning.

Nuri Jeong1,2, Xiao Zheng1,3, Abigail L Paulson1

  • 1Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.

Nature
|April 9, 2025
PubMed
Summary

Researchers found that parvalbumin (PV)-positive interneurons in the hippocampus are crucial for learning new food locations. Reduced activity in these neurons helps mice identify and remember important places for rewards.

More Related Videos

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
07:00

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope

Published on: August 2, 2024

1.3K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K

Related Experiment Videos

Last Updated: May 21, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.5K
Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
07:00

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope

Published on: August 2, 2024

1.3K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Systems Neuroscience

Background:

  • Goal-directed navigation relies on identifying and utilizing significant locations.
  • Neural computations rapidly represent locations and link them to outcomes like food.
  • Mechanisms triggering these computations at behaviorally relevant sites remain unclear.

Purpose of the Study:

  • To investigate the role of parvalbumin (PV)-positive interneurons in the hippocampal CA3 region of mice.
  • To understand how inhibitory activity in these neurons influences the identification and exploitation of new food locations.
  • To determine the impact of altered inhibitory activity on the reactivation of goal locations and outcome associations.

Main Methods:

  • Studied PV-positive interneurons in the mouse hippocampal CA3.
  • Monitored PV interneuron firing during navigation to food locations in food-deprived mice.
  • Utilized sparse optogenetic stimulation to manipulate PV interneuron activity.
  • Assessed the effects of disrupted inhibitory activity on learning and reactivation of goal locations.

Main Results:

  • PV interneurons in CA3 showed reduced firing upon approach and at food goal locations.
  • These inhibitory decreases predicted reward locations and were more pronounced during successful trials.
  • Preventing goal-related firing decreases in PV interneurons impaired learning of goal locations.
  • Disrupting these inhibitory patterns hindered the reactivation of new goal locations post-reward.

Conclusions:

  • Goal-selective and goal-predictive decreases in PV interneuron activity are essential for learning.
  • These inhibitory shifts facilitate the representation of and outcome associations with crucial locations.
  • Understanding these mechanisms provides insight into hippocampal function in navigation and memory.