Visfatin (rs3801266) and Adiponutrin (rs738409) gene single nucleotide polymorphisms in patients with Hashimoto's...

Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism and is also associated with an increased risk of thyroid malignancy. Identifying the exact initiators of the disease could aid in its accurate prevention and treatment. This study aims to clarify the role of Visfatin and Adiponutrin genes in the development of HT.

This case‒control study was carried out on patients from the Internal Medicine, Endocrinology Department, Menoufia University Hospital. Samples are collected from ninety-six patients with HT and ninety-six controls. The findings of this study indicate that the patient group has a significantly higher Body Mass Index (BMI), lipid dysregulation, and thyroid dysfunction compared to the control group. Additionally, the results suggest that the rs3801266 variant of Visfatin and the rs738409 variant of Adiponutrin are associated with the patient group. Specifically, the CC genotype (16.7% vs. 4.2%) and C allele (40.6% vs. 26.0%) of rs3801266, as well as the GG genotype (11.5% vs. 2.1%) and G allele (35.9% vs. 23.4%) of rs738409, are significantly more frequent in patients, indicating a potential genetic predisposition. Anti-Thyroglobulin (Anti-TG) and Anti-Thyroperoxidase (anti-TPO) levels varied significantly across genotypes. CC and TC carriers of rs3801266 had significantly higher anti-TG levels, while GG carriers of rs738409 showed a marked increase in both anti-TPO and anti-TG levels compared to other genotypes.

The involvement of both the Adiponutrin and Visfatin genes is believed to contribute to the pathogenesis of HT, either directly or as a consequence of obesity.