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Updated: May 5, 2026
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
An infant inflammatory myofibroblastoma with TFG-ROS1 fusion: a case report
Hui Jiang1, Junnan Jiang1, Baidong Feng2
1Department of Pathology, The Central Hospital of Yongzhou, Yongzhou, 425000, Hunan Province, China.
Background:
Inflammatory myofibroblastic tumors are extremely rare in the neck of infants, and pathological diagnosis may be challenging. Kinase fusions play an important role in the biology of many inflammatory myofibroblastic tumors, becoming an effective diagnostic method.
Case Presentation:
In this report, we present the case of an East Asian (Han Chinese) patient with rare infant inflammatory myofibroblastoma. DNA-based but not RNA-based next-generation sequencing was used to identify its targetable ROS1 fusions.
Conclusion:
This case highlights the importance of simultaneously detecting DNA and RNA using next-generation sequencing in clinical practice.
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