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Updated: May 15, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Published on: October 25, 2018

IGF2BP2: an m⁶A reader that affects cellular function and disease progression.

Siyi Liu^1,2, Shan Liao³, Junyu He⁴

¹Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, 410013, Hunan, China.

Cellular & Molecular Biology Letters

|April 9, 2025

Summary

This summary is machine-generated.

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) enhances target gene mRNA stability via N⁶-methyladenosine (m⁶A) modification. This regulates key cellular processes and disease progression, offering therapeutic potential.

Keywords:

Angiogenesis Cell stemness Epithelial–mesenchymal transition Ferroptosis IGF2BP2

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Area of Science:

Molecular Biology
Epigenetics
Cancer Research

Background:

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a key reader of N⁶-methyladenosine (m⁶A) modifications.
IGF2BP2 recognizes and binds m⁶A sites on target mRNAs, stabilizing them and influencing gene expression.
Dysregulation of IGF2BP2-mediated m⁶A modification is implicated in various diseases.

Purpose of the Study:

To review the molecular mechanisms of IGF2BP2 in enhancing mRNA stability through m⁶A modification.
To elucidate IGF2BP2's role in regulating cell ferroptosis, epithelial-mesenchymal transition (EMT), stemness, angiogenesis, inflammation, and lipid metabolism.
To provide insights into IGF2BP2's impact on disease progression and its potential as a therapeutic target.

Main Methods:

Literature review focusing on molecular mechanisms.
Analysis of studies investigating IGF2BP2's role in cellular functions and disease.
Synthesis of current research progress on IGF2BP2.

Main Results:

IGF2BP2 enhances mRNA stability of downstream targets via m⁶A binding.
IGF2BP2 significantly impacts ferroptosis, EMT, stemness, angiogenesis, inflammatory responses, and lipid metabolism.
IGF2BP2's functions are crucial for disease progression, particularly in tumors.

Conclusions:

IGF2BP2 plays a critical role in regulating fundamental cellular processes through m⁶A-dependent mRNA stabilization.
Understanding IGF2BP2's mechanisms offers new perspectives on cell functions like ferroptosis and EMT.
Targeting IGF2BP2 presents a promising therapeutic strategy for tumors and other diseases.