Core outcome sets in cancer clinical trials: current status and future opportunities-an EORTC perspective
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View abstract on PubMed
Summary
This summary is machine-generated.Core outcome sets (COS) standardize clinical trial reporting. While available for many cancers, only 10% of surveyed European Organisation for Research and Treatment of Cancer (EORTC) members utilize them due to barriers like outcome volume and time constraints.
Area Of Science
- Clinical Trials Methodology
- Health Outcomes Research
- Oncology Research
Background
- Inconsistent outcome reporting in clinical trials poses a significant challenge.
- Core Outcome Sets (COS) aim to standardize outcome measurement and reporting in specific health areas.
- This study focuses on cancer-specific COS and their adoption in clinical trials.
Purpose Of The Study
- To review existing cancer-specific Core Outcome Sets (COS).
- To assess the awareness and utilization of COS among European Organisation for Research and Treatment of Cancer (EORTC) trialists.
- To identify barriers to COS implementation in cancer clinical trials.
Main Methods
- Exploratory, cross-sectional study design.
- Systematic search of the Core Outcome Measures in Effectiveness Trials (COMET) database for cancer COS.
- Online survey distributed to EORTC members to gauge awareness and use of COS.
Main Results
- 85 cancer-related COS were identified in the COMET database; 69 were relevant to EORTC categorizations.
- Half of the 710 EORTC respondents were unaware of COS.
- Only 10% of respondents utilized available COS, citing outcome volume, time, and infrastructure as key barriers.
Conclusions
- Cancer COS are increasingly available but implementation remains limited.
- Further development is needed to address missing tumor types and involve trialists more in COS creation.
- Enhanced awareness and understanding of COS are crucial for widespread adoption in cancer clinical trials.
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