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Exercise and dietary interventions in the management of diabetic cardiomyopathy: mechanisms and implications

Ling Zhong1, Xiaojie Hou2, Yan Tian3

  • 1Department of Endocrinology and Metabolism, Department of Biotherapy, Laboratory of Diabetes and Metabolism Research, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Cardiovascular Diabetology
|April 9, 2025
PubMed

Insights

Diabetic cardiomyopathy (DCM) is a growing concern in diabetes management. This review explores how exercise and diet can prevent and treat DCM, offering new therapeutic strategies for diabetic patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetes mellitus prevalence is rising globally, increasing cardiovascular disease risk.
  • Diabetic cardiomyopathy (DCM) is a severe complication, leading to heart failure and mortality in diabetic individuals.
  • Current pharmacological treatments for DCM show limitations, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review recent advancements in understanding exercise and dietary interventions for DCM.
  • To elucidate the mechanisms by which these lifestyle modifications impact DCM.
  • To support the development of personalized regimens for DCM prevention and treatment.

Main Methods:

  • Literature review of recent scientific advancements.
  • Synthesis of data on exercise and dietary interventions in DCM.
  • Analysis of underlying pathophysiological mechanisms.

Main Results:

  • Lifestyle modifications, including exercise and diet, offer significant cardiovascular benefits in diabetic patients.
  • These interventions influence DCM pathophysiology through various mechanisms.
  • Personalized exercise and dietary plans show promise in mitigating DCM progression.

Conclusions:

  • Exercise and dietary interventions are crucial for managing DCM.
  • Understanding the mechanisms can lead to tailored therapeutic strategies.
  • Integrating lifestyle modifications is essential for preventing and treating DCM effectively.

Keywords:
DiabetesDiabetic cardiomyopathyDietExerciseLifestyle modifications

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