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Predictive Value of the Systemic Immune-Inflammation Index and CRUSADE Score for Bleeding and Mortality in Older

Ahmet Gürdal1, Ebru Serin1, Mert Sarılar1

  • 1Department of Cardiology, University of Health Sciences, Şişli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|April 10, 2025
PubMed

Insights

A high systemic immune-inflammation index (SII) predicts in-hospital bleeding in older acute coronary syndrome (ACS) patients. A high CRUSADE Bleeding Score (CBS) predicts long-term mortality in these patients.

Area of Science:

  • Cardiology
  • Geriatrics
  • Hematology

Background:

  • Limited research exists on the systemic immune-inflammation index (SII) and bleeding risk in elderly acute coronary syndrome (ACS) patients.
  • This study addresses the gap by investigating SII's predictive value for in-hospital bleeding and the CRUSADE Bleeding Score (CBS) for long-term mortality in this demographic.

Purpose of the Study:

  • To evaluate the systemic immune-inflammation index (SII) as a predictor of in-hospital bleeding.
  • To assess the CRUSADE Bleeding Score (CBS) for predicting long-term mortality in elderly patients with ACS.

Main Methods:

  • The study included 367 patients aged 75 and above with ACS.
  • Multivariate logistic regression identified predictors of in-hospital bleeding.
  • Kaplan-Meier analysis assessed survival curves and long-term mortality.

Main Results:

  • High SII was significantly associated with elevated in-hospital bleeding (p=0.005).
  • Estimated glomerular filtration rate (eGFR) and SII were independent predictors of in-hospital bleeding.
  • High CBS (≥46) was linked to significantly increased all-cause mortality (p=0.001).

Conclusions:

  • The systemic immune-inflammation index (SII) independently predicts in-hospital bleeding in older ACS patients.
  • A high CRUSADE Bleeding Score (CBS) upon admission is associated with increased long-term mortality in this patient group.
Abstract

Keywords:
CRUSADE Bleeding Scoreacute coronary syndromecoronary artery diseaseolder patientssystemic immune‐inflammation index

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