Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.3K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.3K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic Alterations in Multiple Myeloma: From Oncogenesis to Proteasome Inhibitor Resistance.

Cancers·2023
Same author

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs.

Drug delivery·2022
Same author

Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses.

EMBO reports·2021
Same author

The Ubiquitin Proteasome System in Genome Stability and Cancer.

Cancers·2021
Same author

Pathogenic ACVR1<sup>R206H</sup> activation by Activin A-induced receptor clustering and autophosphorylation.

The EMBO journal·2021
Same author

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.

Oncogene·2020

Related Experiment Video

Updated: May 15, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

14.0K

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application.

Chloe Wylie1, Rebecca Rowan2, Dessi Malinova2

  • 1Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, UK.

The FEBS Journal
|April 10, 2025
PubMed
Summary

Extracellular vesicles (EVs) contribute to multiple myeloma (MM) progression and treatment resistance by facilitating communication within the bone marrow microenvironment. Understanding EVs offers potential new therapeutic strategies for this common blood cancer.

Keywords:
biomarkerbone marrow microenvironmentdrug resistanceextracellular vesiclesmultiple myeloma

More Related Videos

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

1.9K
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.8K

Related Experiment Videos

Last Updated: May 15, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

14.0K
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

1.9K
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.8K

Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Multiple myeloma (MM) is a common blood cancer characterized by plasma cell proliferation.
  • Therapeutic resistance is a major challenge in managing MM.
  • The bone marrow microenvironment plays a critical role in MM pathogenesis and resistance.

Purpose of the Study:

  • To review the role of extracellular vesicles (EVs) in multiple myeloma (MM) progression.
  • To summarize how EVs contribute to anticancer treatment resistance in MM.
  • To discuss potential therapeutic applications of EVs in MM.

Main Methods:

  • Literature review of studies on extracellular vesicles and multiple myeloma.
  • Analysis of the role of EVs in cell-to-cell communication within the bone marrow.
  • Synthesis of current knowledge on EV-mediated mechanisms of therapeutic resistance.

Main Results:

  • Extracellular vesicles (EVs) are key mediators of cell-to-cell communication in the bone marrow microenvironment.
  • EVs contribute to multiple myeloma (MM) disease progression.
  • EVs play a significant role in the development of resistance to anticancer therapies in MM.

Conclusions:

  • Extracellular vesicles (EVs) are implicated in multiple myeloma (MM) pathogenesis and therapeutic resistance.
  • Targeting EVs presents a promising avenue for novel MM treatment strategies.
  • Further research into EV biology could lead to improved MM therapies.