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Updated: May 15, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application
Chloe Wylie1, Rebecca Rowan2, Dessi Malinova2
1Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, UK.
Abstract:
Multiple myeloma (MM), characterised by the clonal proliferation of plasma cells in the bone marrow, is the second most common haematological malignancy worldwide. Although there is now an impressive artillery of therapeutics to tackle this condition, resistance remains a prevalent issue. The bone marrow microenvironment performs a crucial role in supporting MM pathogenesis and promoting the development of therapeutic resistance. Extracellular vesicles (EVs), small vesicles that carry bioactive molecules, are a key component of cell-to-cell communication within the bone marrow microenvironment. In this review, we summarise the contribution of EVs to disease progression and anticancer treatment resistance and discuss the potential therapeutic applications of EVs in MM.
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