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Updated: May 15, 2025

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol TRAP Assay
Published on: September 2, 2014
Psychoeducational Program Increases Telomerase Activity in Bipolar Disorder: A Gender-Based Randomized Controlled
G Massa1,2, F Bruno3, L Tarsitani4
1Division of Neuroscience, Department of Psychology, University La Sapienza, Rome, Italy.
Aims:
This randomized controlled trial evaluated the efficacy of a psychoeducational program in enhancing telomerase activity (TA) among patients with bipolar disorder (BD), with a specific focus on gender differences.
Methods:
A total of 62 participants were assigned to either the psychoeducation (PE) group or the control (CTR) group, with TA measured both before and after the intervention.
Results:
Results demonstrated a significant increase in TA in the PE group compared to the controls at the conclusion of the study. Notably, gender-specific analyses revealed that female participants showed significant increases in both TA and delta TA (ΔTA), with ΔTA PE = 0.586 ± 0.273 and ΔTA CTR = -0.251 ± 0.177. In contrast, male participants exhibited significant changes only in ΔTA, with ΔTA PE = 0.257 ± 0.138 and ΔTA CTR = -0.144 ± 0.1194.
Conclusion:
These findings suggest that psychoeducational interventions have differential gender-specific effects, underscoring the importance of personalized approaches in the treatment of BD.
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