Acoustic ejection mass spectrometry: the potential for personalized medicine
1SCIEX, Concord, ON, Canada.
Expert Review of Proteomics
|April 10, 2025
Summary
Acoustic Ejection Mass Spectrometry (AEMS) offers a novel, high-throughput platform for personalized medicine. This technology accelerates analysis with minimal sample prep, advancing TDM, proteomics, and metabolomics.
Area of Science:
- Analytical Chemistry
- Biotechnology
- Personalized Medicine
Background:
- Personalized medicine (PM) tailors healthcare using individual genetic, environmental, and lifestyle data.
- Traditional methods often lack the speed and scalability required for PM applications.
- Acoustic Ejection Mass Spectrometry (AEMS) presents a novel solution for high-throughput mass spectrometry (MS) analysis.
Purpose of the Study:
- To explore the potential of AEMS in key personalized medicine applications.
- To highlight AEMS's advantages in speed, sample preparation, and data quality.
- To discuss AEMS's role in advancing TDM, proteomics, metabolomics, and MS imaging.
Main Methods:
- Acoustic Ejection Mass Spectrometry (AEMS) for high-throughput MS readout.
- Integration of AEMS with orthogonal separation techniques like differential mobility spectrometry (DMS).
- Development of high-throughput data processing tools.
Main Results:
- AEMS achieves analytical speeds of one sample per second with high data quality.
- AEMS minimizes sample preparation and is compatible with automation.
- AEMS enables direct analysis of complex biological matrices.
- Integration with DMS enhances isomer discrimination capabilities.
Conclusions:
- AEMS is a robust and scalable platform for personalized medicine.
- AEMS simplifies workflows and accelerates analysis in critical PM applications.
- Further development of data processing tools will enhance AEMS's impact on personalized medicine.
Keywords:
Personalized medicineacoustic ejection mass spectrometryhigh-throughput analysismass spectrometry imagingmetabolomicsproteomicstherapeutic drug monitoringMore Related Videos
08:08Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
16.0K
07:55Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
Published on: June 21, 2019
5.7K
Related Concept Videos
01:19MALDI-TOF Mass Spectrometry
4.6K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.6K
01:33Peptide Identification Using Tandem Mass Spectrometry
6.2K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.2K
01:21Mass Spectrometry: Complex Analysis
654
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
654
01:19Mass Spectrometry: Overview
3.6K
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electrospray ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave...
3.6K
01:12Electrospray Ionization (ESI) Mass Spectrometry
672
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
672
01:16Mass Spectrometers
4.9K
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
4.9K