Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

144
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
144
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

91
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
91
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

156
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
156
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

108
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
108
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Cancer Therapies02:49

Cancer Therapies

7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytotoxic Activity of Essential Oils from Middle Eastern Medicinal Plants on Malignant Keratinocytes.

Molecules (Basel, Switzerland)·2025
Same author

Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients.

Case reports in oncology·2025
Same author

Vitamin D: What role in obesity-related cancer?

Seminars in cancer biology·2025
Same author

Breath-hold diving as a tool to harness a beneficial increase in cardiac vagal tone.

Respiratory physiology & neurobiology·2025
Same author

Impact of osteopathic tests on heart rate and heart rate variability: an observational study on osteopathic students.

Journal of osteopathic medicine·2025
Same author

Malignant tumors in vagal-innervated organs: Exploring its homeostatic role.

Cancer letters·2025

Related Experiment Video

Updated: May 15, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.1K

Rethinking corticosteroids use in oncology.

Pierrick Martinez1, Jean-Marc Sabatier2

  • 1Association Cancer et Métabolisme, Nîmes, France.

Frontiers in Pharmacology
|April 10, 2025
PubMed
Summary

Corticosteroids (CSs) manage cancer symptoms but may harm survival by altering metabolism and the microbiome. Alternative strategies like ketogenic diets and vitamin D show promise for safer cancer care.

Keywords:
corticosteroidsglucocorticoidsglutaminolysisglycolysismicrobiomerenin-angiotensin systemvitamin D

More Related Videos

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
08:00

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

17.8K
A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

29.9K

Related Experiment Videos

Last Updated: May 15, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.1K
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
08:00

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

17.8K
A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

29.9K

Area of Science:

  • Oncology
  • Pharmacology
  • Metabolic research

Background:

  • Corticosteroids (CSs) are commonly used in cancer care for symptom management and anti-inflammatory effects.
  • Long-term CS use is linked to adverse outcomes, including reduced patient survival and accelerated tumor progression.
  • Key mechanisms involve altered glucose/glutamine metabolism, disrupted vitamin D, and microbiome changes.

Purpose of the Study:

  • To evaluate the risks associated with long-term corticosteroid use in oncology.
  • To explore alternative therapeutic strategies that mimic CS benefits while mitigating adverse effects.
  • To advocate for a reevaluation of corticosteroid protocols in cancer treatment.

Main Methods:

  • Literature review and synthesis of current research on corticosteroids in cancer.
  • Analysis of metabolic pathways (glucose, glutamine) affected by CSs.
  • Investigation of alternative interventions (ketogenic diets, fasting, sartans, vitamin D).

Main Results:

  • Corticosteroids can negatively impact cancer patient survival and promote tumor growth.
  • Metabolic dysregulation, vitamin D deficiency, and microbiome alterations are critical factors.
  • Emerging strategies show potential to offer similar benefits with reduced oncologic risks.

Conclusions:

  • A critical reevaluation of corticosteroid use in cancer patients is warranted.
  • Alternative and complementary therapies may provide safer options for symptom management and supportive care.
  • Further research is essential to develop and validate novel therapeutic strategies for cancer treatment.