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Related Experiment Video

Updated: Jul 9, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Association between bone mineral density and stroke: a meta-analysis.

Peng Zhao1, Huaxia Sun2

  • 1Department of Neurology, The Second Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, China.

Frontiers in Neurology
|April 10, 2025
PubMed
Summary

Lower bone mineral density (BMD) is linked to a higher risk of stroke. This association is particularly significant in women, indicating a potential link between bone health and cerebrovascular events.

Keywords:
bone densitycerebrovascular accidentosteopeniaosteoporosisstroke

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Published on: December 19, 2025

Area of Science:

  • Bone biology and metabolism
  • Neurology and cerebrovascular disease
  • Epidemiology and public health

Background:

  • The relationship between bone mineral density (BMD) and stroke risk is not fully understood, with existing studies showing inconsistent findings.
  • Understanding this association is crucial for identifying individuals at higher risk for stroke and developing preventative strategies.

Purpose of the Study:

  • To systematically evaluate the association between reduced bone mineral density (BMD) and the risk of stroke.
  • To determine if low BMD is a significant predictor of incident stroke across diverse populations.

Main Methods:

  • A comprehensive systematic literature search was conducted across Medline, Embase, and the Cochrane Database of Systematic Reviews up to January 2025.
  • Pooled analyses of 13 cohort studies, including 146,758 participants, were performed using random-effects models to assess the risk of stroke associated with reduced BMD.

Main Results:

  • A 1 standard deviation (SD) reduction in BMD was significantly associated with an increased risk of stroke (RR, 1.24; 95% CI, 1.09-1.40).
  • Subgroup analyses revealed this association was more pronounced in female individuals (RR, 1.28; 95% CI, 1.09-1.51) compared to male individuals (RR, 1.04; 95% CI, 0.99-1.10).
  • Individuals with osteoporosis or osteopenia demonstrated a substantially higher risk of incident stroke (RR, 1.59; 95% CI, 1.22-2.08).

Conclusions:

  • Reduced bone mineral density (BMD) is a significant risk factor for stroke.
  • Female individuals with lower BMD face a higher risk of stroke compared to their male counterparts.
  • The findings underscore the importance of considering bone health in stroke risk assessment, particularly in women.