Serum Hormone Levels in Female Patients With Atrophic Rhinitis

Area of Science:

• Otolaryngology
• Endocrinology
• Nutritional Science

Background:

• Atrophic rhinitis is a chronic nasal inflammation causing tissue changes and crusting.
• Primary atrophic rhinitis causes are unclear but linked to nutrition and hygiene, affecting women of reproductive age.
• Hormonal influences are suspected but under-researched in atrophic rhinitis.

Purpose of the Study:

• To investigate the association between female hormones (estrogen, progesterone), nutritional status, and primary atrophic rhinitis.
• To compare hormone and nutrient levels in women with atrophic rhinitis versus healthy controls.

Main Methods:

• A cross-sectional study involving 60 female patients with primary atrophic rhinitis and 60 age-matched healthy controls.
• Serum estrogen, progesterone, vitamin D3, B12, protein, iron, and calcium levels were measured using ELISA and standard assays.
• Statistical analysis was performed using SPSS, with p<0.05 considered significant.

Main Results:

• Significantly lower serum estrogen levels were observed in patients with atrophic rhinitis compared to controls (p<0.0001).
• No significant difference in progesterone levels was found between cases and controls (p>0.05).
• Patients with atrophic rhinitis showed significantly lower levels of vitamin D3, B12, protein, iron, and calcium (p<0.05).

Conclusions:

• Low estrogen levels are associated with primary atrophic rhinitis in women.
• Poor nutritional status, indicated by deficiencies in key vitamins and minerals, is also linked to atrophic rhinitis.
• Findings suggest a combined role of hormonal imbalance and nutritional deficiencies in the development of atrophic rhinitis.