Hand, Foot, and Mouth Disease in a Patient With Psoriasis: A Case Report

João A Martins1, Catarina Morais1, Pedro Ferreira1

  • 1Family Medicine, Unidade Local de Saúde-Almada Seixal, Almada, PRT.

Cureus
|April 10, 2025
PubMed

Insights

Adults can contract Hand, Foot, and Mouth Disease (HFMD), a viral infection. This case highlights HFMD worsening pre-existing skin conditions like psoriasis.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Virology

Background:

  • Hand, Foot, and Mouth Disease (HFMD) is a common childhood viral illness, rarely seen in adults.
  • Patients with chronic skin conditions may experience exacerbations following infections with agents that target the skin.

Observation:

  • A 48-year-old male with a history of plaque psoriasis presented with painful oral and cutaneous lesions (vesicles, blisters, pustules).
  • Lesions were located on the perioral area, elbows, hands, and soles of the feet.
  • Enterovirus A71 infection was confirmed via blood tests.

Findings:

  • The patient, despite lacking clear epidemiological contacts, was diagnosed with HFMD.
  • The viral infection led to a significant flare-up of his pre-existing plaque psoriasis.

Implications:

  • Healthcare professionals should consider HFMD in adults presenting with unexplained cutaneous and oral symptoms.
  • The potential for HFMD to exacerbate chronic dermatological conditions necessitates heightened clinical awareness.