Anaplastic Lymphoma Kinase Rearrangement-Positive Pulmonary Adenocarcinoma With Scattered Bilateral Breast...

A 67-year-old woman was referred to our hospital because of chest X-ray abnormalities. Chest computed tomography revealed a lobulated lung mass in the right lower lobe and multiple scattered nodules in both breasts. The lung mass was diagnosed as anaplastic lymphoma kinase (ALK) rearrangement-positive pulmonary adenocarcinoma through a transbronchial biopsy. Histological findings of bilateral needle biopsy of breast nodules were nearly identical to that of lung nodule, and fluorescence in situ hybridization showed ALK rearrangement. These results confirmed the diagnosis of ALK rearrangement-positive pulmonary adenocarcinoma with bilateral scattered breast metastases and its metastatic form of lung adenocarcinoma, which is rare.