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Updated: May 15, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
An Uncommon Association: Eltrombopag and Autoimmune Hepatitis
Fady Salama1, Hassnain Syed1, Nimish Thakral1
1Department of Digestive Disease and Nutrition, University of Kentucky, Lexington, Kentucky, USA.
Abstract:
Autoimmune hepatitis (AIH) is an immunological disorder of the liver characterized by hepatic necroinflammation due to the break in self-tolerance to autoantigens. Many medications have been linked to drug induced AIH. A review of the literature reveals no documented association between Eltrombopag and AIH. Eltrombopag is a thrombopoietin receptor agonist used to help manage thrombocytopenia in immune mediated thrombocytopenia and chronic liver disease. Here, we present a case of a 59-year-old female with refractory thrombocytopenia who was started on Eltrombopag, and later developed AIH.
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