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Updated: May 15, 2025

Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria
Clara Dessenne1, Christophe Mariller1, Olivier Vidal1
1Université Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.
Abstract:
Bacterial adhesins play a central role in host-pathogen interactions, with many specifically targeting glycans to mediate bacterial colonization, influence infection dynamics, and evade host immune responses. In this review, we focus on bacterial pathogens identified by the World Health Organization as critical threats to public health and in urgent need of new treatments. We summarize glycoconjugate targets identified in the literature across 19 bacterial genera and species. This comprehensive review provides a foundation for the development of innovative therapeutic strategies to effectively combat these pathogens.
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